Vitamin D: The "Sunshine" Vitamin & Essential Tremor
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Vitamin D insufficiency affects almost 50% of the population worldwide. An estimated 1 billion people worldwide, across all ethnicities and age groups, have a vitamin D deficiency (VDD). This pandemic of hypovitaminosis D can mainly be attributed to lifestyle (for example, reduced outdoor activities) and environmental (for example, air pollution) factors that reduce exposure to sunlight, which is required for ultraviolet-B (UVB)-induced vitamin D production in the skin.
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The primary source of vitamin D for children and adults is exposure to natural sunlight.
Obtaining sufficient vitamin D from natural food sources alone is difficult. Consumption of vitamin D-fortified foods and exposure to some sunlight are essential for maintaining a healthy vitamin D status. Dietary supplements might be required to meet the daily need for vitamin D in some groups of people.
Vitamin D supplements may interact with several types of medications. Corticosteroids can reduce calcium absorption, which results in impaired vitamin D metabolism.
Obtaining sufficient vitamin D from natural food sources alone is difficult. Consumption of vitamin D-fortified foods and exposure to some sunlight are essential for maintaining a healthy vitamin D status. Dietary supplements might be required to meet the daily need for vitamin D in some groups of people.
Vitamin D supplements may interact with several types of medications. Corticosteroids can reduce calcium absorption, which results in impaired vitamin D metabolism.
Inadequate vitamin D status also correlates with a greater risk for cognitive decline in the elderly, suggesting that optimal levels may promote healthy brain aging. Because the brain expresses vitamin D receptors (VDRs) and can synthesize the active form of the hormone, the possible cognitive enhancing effects of vitamin D may reflect a primary action in the brain rather than a result of secondary systemic effects.
Vitamin D has been identified as a key factor in dopaminergic neurogenesis and differentiation. Consequently, developmental vitamin D deficiency has been linked to disorders of abnormal dopamine signaling with a neurodevelopmental basis.
Evidence of vitamin D’s role as a mediator of dopaminergic development by showing that it increases neurite outgrowth, neurite branching, presynaptic protein re-distribution, dopamine production and functional release in various in vitro models of developing dopaminergic cells including SH-SY5Y cells, primary mesencephalic cultures and mesencephalic/striatal explant co-cultures.
This study continues to establish vitamin D as an important differentiation agent for developing dopamine neurons, and now for the first time shows chronic exposure to the active vitamin D hormone increases the capacity of developing neurons to release dopamine.
Evidence of vitamin D’s role as a mediator of dopaminergic development by showing that it increases neurite outgrowth, neurite branching, presynaptic protein re-distribution, dopamine production and functional release in various in vitro models of developing dopaminergic cells including SH-SY5Y cells, primary mesencephalic cultures and mesencephalic/striatal explant co-cultures.
This study continues to establish vitamin D as an important differentiation agent for developing dopamine neurons, and now for the first time shows chronic exposure to the active vitamin D hormone increases the capacity of developing neurons to release dopamine.
Several studies show the link between vitamin D and depression. a study, shows optimal levels of vitamin D in the bloodstream are necessary to preserve the neurological development and protect the adult brain.
Balanced dietary intake is a well-established lifestyle factor in maintaining cognition during ageing. Due to its effect on dopamine pathway in the brain, vitamin D can be a useful therapeutic agent used as an intervention therapy to be combined with existing treatments for Parkinson’s disease.
In conclusion, vitamin D is essential to maintain important functions of the body such as neurodevelopment.
Balanced dietary intake is a well-established lifestyle factor in maintaining cognition during ageing. Due to its effect on dopamine pathway in the brain, vitamin D can be a useful therapeutic agent used as an intervention therapy to be combined with existing treatments for Parkinson’s disease.
In conclusion, vitamin D is essential to maintain important functions of the body such as neurodevelopment.
Vitamin D is vital for our body as it regulates calcium homeostasis and maintains bone integrity.
Vitamin D aids in the function of neuronal and glial tissue and the many health consequences in a person with vitamin D deficiency.
Vitamin D aids in the function of neuronal and glial tissue and the many health consequences in a person with vitamin D deficiency.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132681/#:~:text=Its%20deficiency%20has%20been%20linked,mellitus%2C%20autism%2C%20and%20schizophrenia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356951/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356951/
This page provides general info only. Consult your medical provider for care decisions.
