DSF's Director of Medical Research
Dr. Darlene A. Mayo (née Lobel) is a board certified neurosurgeon who is internationally known as an expert in the treatment of essential tremor and other movement disorders. She earned a Bachelor of Science degree from Duke University and her Medical Doctorate from Medical College of Georgia. She completed clinical fellowships in Stereotactic and Functional Neurosurgery and Epilepsy at UCLA and Emory, finishing training in 2007. She also completed two research fellowships, first in Grenoble, France, where she worked for two years with Professor Alim-Louis Benabid at Clinatec on the clinical protocol and implementation of a brain computer interface system, designed to aid quadriplegic patients. She then completed a fellowship in the Neural Engineering Laboratory at Mayo Clinic in Rochester, Minnesota, where she worked on the design and preclinical assessment of an intraspinal microstimulation system to restore neurologic function after spinal cord injury. Dr. Mayo worked for two years as a Neurosurgeon and Assistant Professor at University of Florida-Jacksonville and for nearly five years as a Neurosurgeon and Associate Professor of Neurosurgery and Biomedical Engineering at the Cleveland Clinic, where she had a busy practice treating patients with essential tremor and Parkinson’s disease. She also co-led an essential tremor support group for two years in the Cleveland area.
Dr. Mayo is a renowned author with over 25 publications, including peer-reviewed manuscripts, books, and book chapters, and is an internationally acclaimed speaker. She has spent years researching ways to improve tremors, having served as a consultant and lead investigator on clinical trials in the U.S. and abroad. She also serves as an ad-hoc reviewer for neurosurgical and biomedical engineering journals, and serves on grant review panels, as reviewer and as chair. Her expertise is widely sought after as a reviewer, invited speaker, and as an expert in deep brain stimulation by other scientists and researchers.
She has a passion for teaching, which extends not only to medical students and residents in training, but to her patients and to anyone who is looking to learn more about medical conditions.
Dr. Mayo is an internationally acclaimed speaker and holds leadership positions in the Council of State Neurosurgical Societies. She has served as Co-Investigator and Consultant in clinical trials in the US and in France, has authored numerous publications, including peer-reviewed manuscripts and book chapters, serves as an ad-hoc reviewer for neurosurgical and biomedical engineering journals, and serves on grant review panels, as reviewer and as chair. Her expertise is widely sought after as a reviewer, invited speaker, and as an expert in deep brain stimulation by other scientists and researchers.
PUBLICATIONS 1. Frizon LA, Hogue O, Achey R, Nagel S, Machado AM, Lobel DA. Quality of Life Improvement Following DBS for Parkinson’s Disease: Development of a prognostic model. Neurosurgery. 2018, in press.
2. Frizon LA, Shao J, Maldonado-Naranjo AL, Lobel DA, Fernandez H, et al. The Safety and efficacy of using the O-arm intraoperative imaging system for deep brain stimulation lead implantation. Neuromodulation. 2017 Dec 20.
3. Lee BL, Jones J, Lang M, Achey R, Dai L, Lobel DA, et al. Early outcomes after intrathecal baclofen therapy in ambulatory patients with multiple sclerosis. Journal of Neurosurgery. 2017:1-7.
4. Matias CM, Frizon LA, Nagel SN, Lobel DA, and Machado AM. Deep brain stimulation outcomes in patients implanted under general anesthesia with frame-based stereotaxis and intraoperative MRI. Journal of Neurosurgery. 2018:1-7.
5. Achey RL, Yamamoto E, Sexton D, Hammer C, Lee BS, Butler RS, Nagel SJ, Machado AG, and Lobel DA. Prediction of depression and anxiety via patient-assessed tremor severity, not physician-reported motor symptom severity, in patients with Parkinson’s disease or essential tremor who have undergone deep brain stimulation. Journal of Neurosurgery. 2018:1-10.
6. Maldonado-Naranjo AL, Frizon LA, Sabharwal NC, Xiao R, Hogue O, Lobel DA, et al. Rate of complications following spinal cord stimulation paddle electrode removal. Neuromodulation. 2017 Aug 22.
7. Frizon LA, Hogue O, Wathen C, Yamamoto E, Sabharwal NC, Jones J, Volovetz J, Maldonado-Naranjo AL, Lobel DA, Machado AG, Nagel SJ. Subsequent Pulse Generator Replacement Surgery Does Not Increase the Infection Rate in Patients With Deep Brain Stimulator Systems: A Review of 1537 Unique Implants at a Single Center. Neuromodulation. 2017 Jul;20(5):444-449.
8. Silva D, Matias C, Bourne S, Nagel S, Machado A, Lobel D. Effects of chronic alcohol consumption on long-term outcomes of thalamic deep brain stimulation for essential tremor. .J Clin Neurosci. 2016 Sep;31:142-6. Epub 2016 Jul 9.
9. Lobel DA, Achey R, Brennan R, Rastogi A, Ajiboye AB. Enhancement of Cortical Signals to Improve Brain Machine Interface Performance by Inducing Mirror Neuron Network Activation. Neurosurgery, 2015 Aug;62 Suppl 1:201-2.
10. Lobel DA, Kahn M, Rosen CL, Pilitsis JG. Medical student education in neurosurgery: optional or essential? Teaching and Learning in Medicine, 2015;27(2):201-4.
11. Nagel SJ, Machado AM, Gale JT, Lobel DA, Pandya M. Preserving cortico-striatal function: Deep brain stimulation in Huntington’s Disease, Frontiers in Systems Neuroscience, 2015 Mar 11;9:32.
12. Grahn PJ, Lee KH, Kasabeh A, Mallory GW, Hachmann JT, Dube JR, Kimble CJ, Lobel DA, Bieber A, Jeong JH, Bennet K, Lujan JL. Wireless control of intraspinal microstimulation in a rodent model of paralysis. Journal of Neurosurgery, 2014 Dec 5:1-11.
13. Grahn PJ, Mallory GW, Berry BM, Hachmann JT, Lobel DA, and Lujan JL. Restoration of motor function following spinal cord injury: toward a closed-loop neural prosthesis. Frontiers in Neuroscience. 2014 Sep 17;8:296.
14. Matias CM, Amit A, Lempka SF, Ozinga JG 4th, Nagel SJ, Lobel DA, Machado AG. Long-term Outcomes After Replacement of Percutaneous Leads With Paddle Leads in a Retrospective Cohort of Patients With Spinal Cord Stimulation Systems. Neurosurgery. 2014 Oct;75(4):430-6.
15. Lobel DA and Lee KH. Brain Machine Interface and Limb Reanimation Technologies: Restoring function after spinal cord injury through development of a bypass system. Mayo Clinic Proceedings, 2014; 89(5): 708-714.
16. Lobel DA, Schirmer CM, Elder JB, Roitberg B. In Reply: Simulating Ventriculostomy. Neurosurgery. Dec 30 2013. PMID: 24378830.
17. Hachmann JT, Jeong JH, Grahn PJ, Mallory GW, Evertz LQ, Bieber AJ, Lobel DA, Bennet KE, Lee KH, and Lujan JL. Large animal model for development of functional restoration paradigms using epidural and intraspinal stimulation. PLOS ONE. 2013; 8(12): e81443.
18. Ghobrial GM, Anderson PA, Chitale R, Campbell PG, Lobel DA, and Harrop JS. Simulated Spinal Cerebrospinal Fluid Leak Repair: an Educational Model with Didactic and Technical Components. Neurosurgery. 2013; 73(Suppl): S111-115.
19. Chitale R, Ghobrial GM, Lobel D, and Harrop J. Simulated Lumbar Minimally Invasive Surgery Educational Model With Didactic and Technical Components. Neurosurgery. 2013; 73(Suppl): S107-110.
20. Schirmer CM, Elder JB, Roitberg B, and Lobel DA. Virtual Reality Based Simulation Training for Ventriculostomy: An Evidence Based Approach. Neurosurgery. 2013; 73(Suppl): S66-73.
21. Lobel DA, Elder JB, Schirmer CM, Bowyer M, and Rezai AR. A Novel Craniotomy Simulator Provides a Validated Method to Enhance Education in the Management of Traumatic Brain Injury. Neurosurgery. 2013; 73(Suppl): S57-65.
22. Harrop JS, Lobel DA, Bendock B, Sharan A, Rezai AR. Developing Neurosurgical Simulation: An Overview. Neurosurgery. 2013; 73(Suppl): S25-29.
23. Mazzola CA, Lobel DA, Krishnamurthy S, Bloomgarden GM, Benzil DL. Efficacy of Neurosurgery Resident Education in the New Millenium: The 2008 Council of State Neurosurgical Societies Post-Residency Survey Results. Neurosurgery. August 2010; 67(2):225-233.
24. Tang M and Lobel DA. Severe Traumatic Brain Injury: Maximizing outcomes. Mount Sinai Journal of Medicine. 2009;76(2):119-128.
25. Hadman M, Chiu F-C, Lobel D, and Borlongan CV. Commentary: Standardized Embryonic Tissue Collection and Hibernation Procedures, and MRI-Based Graft Assessment: Advancing Neural Transplantation Therapy for Huntington’s Disease. Cell Transplantation. 2003; 12(7): 677-678.
26. Lobel DA, Hadman M, Sanberg PR, and Borlongan CV. Early Intracerebral and Intra-arterial Transplantation of Human Umbilical Cord Blood Cells into an Ischemic Rat Brain Model. Experimental Neurology. 2003; 181(1):97-98.
Invited, Non-Peer Reviewed
1. Harrop JS and Lobel DA. Simulation Symposium: Simulation-based Neurosurgical Training. Congress Quarterly. Fall 2012.
2. Lobel DA, Rezai AR, and Harrop JS. Simulation Symposium-PC11:Simulation-based Neurosurgical Training. Congress Quarterly. Fall 2011.
3. Lobel DA and Rezai AR. Frontiers in Neurosurgery: Simulation in Resident Education. Congress Quarterly. Summer 2011.
4. Lobel DA. Robotics and Technology in Education. Congress Quarterly. Spring 2011.
5. Lobel DA, Park YP, and Lee MR. Surgical Treatment of Epilepsy in Children. Contemporary Neurosurgery. 2004; 26(2):1-8.
1. Lobel DA, Lee MR: Brain Stem Gliomas in Goodrich JT (ed): Neurosurgical Operative Atlas (2nd Edition): Pediatric Neurosurgery, Thieme, 2008, pp 275-280.
2. Lobel DA, Lee MR, Duhaime A-C: Pediatric Intensive Care Unit Management of Neurosurgical Disease in Wheeler DS, Wong HR, Shanley TP (eds): Pediatric Critical Care Medicine: Basic Science and Clinical Evidence, Springer, 2007, pp 884-893.
1. Mayo MD FAANS, Darlene A. Stop Spilling Your Soup! The Complete Essential Tremor Solution. Stop Spilling Your Soup, LLC, Jacksonville, FL, 2018.
Darlene A Mayo MD FAANS
Diann Shaddox Foundation for Essential Tremors
241 Boxelder Drive, Aiken, SC 29803
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